Amoxicillin is one of the most prescribed antibiotics in the UK. On the contrary, metronidazole is significantly less prescribed by GPs, mainly because of preferred use in dental infections. Prescriptions which are fulfilled in the pharmacy for a combination treatment with amoxicillin and metronidazole are almost always issued by a dentist rather than GP. The obvious question to ask is: can you take amoxicillin and metronidazole together? The answer to that question straightforward. However, I will provide reasoning behind the concomitant treatment and contrast both antibiotics.