Nexium Control is a branded version of esomeprazole drug, available without a prescription for heartburn treatment and acid reflux in adults over 18 years of age. Nexium Control is available as gastro-resistant tablets and capsules, both containing 20mg of esomeprazole. Esomeprazole of few drugs which are collectively called Proton Pum Inhibitors (PPIs). Nexium Control is advertised as a product that gives relief from a single dose for 24 hours. Nexium Control review – summary of the post:
- Review of licensed use of Nexium Control
- Nexium Control review of possible side effects
- Interactions and effectiveness of Nexium Control
- Comparison Of Nexium Control (esomeprazole) to omeprazole
- Can you get Nexium Control prescribed on the NHS?
- Where can buy Nexium Control?
What is Nexium Control used for?
Esomeprazole belongs to a group of drugs called Proton Pump Inhibitors (PPIs), a common group of drugs used to inhibit stomach acid production. When prescribed, PPIs have other indications, including treatment of ulcers and eradication of Helicobacter pylori.
Over the counter Nexium Control is licensed for the short-term treatment of heartburn, a burning sensation in the upper part of the gastrointestinal tract, the chest, and throat, caused by acid reflux. The general advice is to see a GP if symptoms are not resolved after 14 days of Nexium use.
Nexium Control may not give immediate relief of the symptoms, although the onset of action (the time it takes to work) is about one hour. It may take 2-3 days of continuous use before symptoms resolve.
Nexium Control review of possible side effects
As with all medicines, there is a risk of experiencing some side effects when Nexium Control is taken. Although the whole list of possible side effects is long, the most common side effects (1 in 10 people may be affected) include:
- Upset stomach (diarrhoea, constipation, flatulence/wind, stomach pain)
- Vomiting (being sick) and nausea (feeling sick)
- Growth of polyps in the stomach
List of under uncommon (1 in 100), rare (1 in 1000), and very rare side effects can be found in the product information leaflet.
Nexium Control review of drug interactions
Like many other drugs, Nexium Control is metabolised by the liver. Nexium Control competes in the liver for some enzymes, and therefore affected drugs cannot be fully metabolised (broken down to its inactive form). As a result, concomitant use with other medicines may increase their concentration. Some drugs affected include:
For more information on interactions between Nexium Control and other drugs, read the product information leaflet or speak to your pharmacist.
Nexium Control – the effectiveness
Several studies confirm the effectiveness of esomeprazole 20mg. When compared with placebo (a dummy pill) in randomised studies (patient not aware of what treatment they receive), esomeprazole showed to be an effective treatment of heartburn symptoms, resulting in complete settlements of heartburn symptoms in patients who took a single dose of Nexium Control 20mg tablet, every 24 hours, in 2 week period (EMA, N.D.).
Is Nexium (esomeprazole) the best PPI available?
Scientific research suggests that esomeprazole has improved the pharmacokinetic profile, resulting in more effective control of stomach acid production as compared to omeprazole or other PPIs (Johnson, 2003). There is also less variability in how different people respond to treatment with esomeprazole (ibid). When compared to omeprazole 20mg, esomeprazole 20mg and 40mg had superior outcomes in three different areas: consistency, duration of action 24-hours cycle and the overall reduction of stomach acid production (Dent, 2003). As suggested by different scientific papers esomeprazole is more effective PPI then omeprazole. A large trial of over 5000 patients confirmed that esomeprazole 40mg is more efficacious than lansoprazole, another PPI (Scott, 2002).
Esomeprazole vs omeprazole? What is the difference?
Both drugs, esomeprazole, and omeprazole belong to the same group of drugs, PPIs. Both drugs have the same chemical structure; however, a different arrangement of atoms ‘in space’ (the scientific name for this type of structure is optical isomer). This allowed AstraZeneca to market Nexium as a different drug to omeprazole, consequently calling it esomeprazole.
Can Nexium Control be prescribed on NHS?
Nexium Control is the brand name of esomeprazole sold to the public in supermarkets and pharmacies only. Branded esomeprazole used by pharmacies which is supplied to patients on prescription is called Nexium. Prescription-only Nexium contains 20mg or 40mg of esomeprazole (pack size of 28 tablets).
The NICE guide does not specify which PPI should be offered in the first place, in the management of dyspepsia/heartburn. However, in practice, esomeprazole (generic or Nexium brand) and Nexium are considerably less commonly prescribed than other PPIs, mainly due to higher cost of both drugs.
Supply of Nexium 20mg on NHS cost around £18 per box of 28 tablets, equivalent generic esomeprazole 20mg tablets costs around £2.50, whereas omeprazole 20mg capsules (see most prescribed drugs in the UK) cost around £1. Some pharmacies may have ‘special deals‘ with pharmaceutical suppliers, which allows them to supply Nexium tablets instead of cheaper, generic versions of esomeprazole. Overall Nexium can be prescribed on NHS prescription; however, due to the cost of the drug, this is not commonly done. Instead, ‘generic’ esomeprazole is prescribed or another PPI.
Where to buy Nexium Control?
- Take control of your heartburn with Nexium Control, For 24 hour protection from heartburn and acid reflux
- Clinically proven to relieve night-time heartburn for a good night’s sleep, Just 1 pill a day for 24-hour protection and zero heartburn
- How to use: The tablets should be swallowed whole, Do not crush or chew the tablets, Read the package leaflet before use
Nexium Control is licensed as a general sale medication, which means it can be sold in any retail outlet. Nexium Control can be purchased from all supermarkets including Tesco, Asda, Sainsbury’s, Morrisons and others. Most pharmacies stock this product. Nexium Control is also available widely on the internet, with Amazon stocking both tablets and capsules.
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Dent, J. (2003), Review article: pharmacology of esomeprazole and comparisons with omeprazole. Alimentary Pharmacology & Therapeutics, 17: 5-9. Available at: https://doi.org/10.1046/j.1365-2036.17.s1.2.x Accessed on 20/11/2019
EMA (N.D.). Nexum control 20mg gastro-resistant tablets. Summary product characetereisitics. Available at: https://www.ema.europa.eu/en/documents/product-information/nexium-control-epar-product-information_en.pdf Accessed on 20/11/2019
Johnson, DA (2003). Review of esomeprazole in the treatment of acid disorders. Expert Opin Pharmacother. 2003 Feb;4(2):253-64. Available at: https://www.tandfonline.com/doi/abs/10.1517/146565126.96.36.199 Accessed on 20/11/2019
Scott, L.J., Dunn, C.J., Mallarkey, G. et al. Drugs (2002) 62: 1503. https://doi.org/10.2165/00003495-200262100-00006 Accessed on 20/11/2019